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Galveston Bay, Texas

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Ashley Davis
Ashley Davis
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Actos and Avandia

3 comments

On June 6, 2007, the drug Actos was issued a “black box” warning that the drug might trigger heart failure. Although this warning has been issued, the warning actually has nothing to do with Actos itself but just the class of drugs that it is associated with (which includes Avandia).

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Avandia and Actos inrease the tendency for the body to accumulate fluids due to an inadequate pumping of the heart (which is a complication of diabetes). This kind of inadequate pumping can result in heart failure.

Although there is still much debate on whether or not Avandia and Actos do indeed cause heart failure, it is good to know the risks and to consult your doctor

3 Comments

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  1. jibber says:
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    I would like to point out that your article is highly misleading. Actos and Avandia have different outcomes with regards to cardiovascular mortality.
    Actos has actually been proven to reduce deaths from cardiovascular endpoints in the PROactive study, a large randomised controlled trial in patients with existing cardiovascular disease and diabetes. Avandia, on the other hand has shown in a number of meta analases to increase death and numbers of heart attacks. Therefore Avandia has much stronger FDA warnings associated with it than Actos.
    Your article seems to confuse the fact that Heart attacks are different from heart failure. The black box warning is on both products because of the increased risk of heart failure. However, no evidence has shown an increase in death due to heart failure.

  2. Kongphop says:
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    I was put on Actos approx 1 yr ago and ate the same amount as always and I went from 234 lbs to 280 lbs very quickly. My Dr. doubled my water pill and within 7 days I lost 14 lbs of water. I was on the verge of congestive heart failure, according to the Doctor. I became weak and had a hard time breathing. Five days ago I went to the E/R and was put into the hosp for 4 days for a cath and observed for 3 more days. I also know that I have taken Avandia before and have checked with Pharmacies trying to locate when I was perscribed Avanida and by whom and can’t find it. I know I was perscribed this drug for Type II. Any ideas on how I could find that out. Avandia should know but I’m sure they would never devolge that information. Any help would be appreciated. Thanks, Konghhop

  3. Kongphop says:
    up arrow

    I was put on Actos approx 1 yr ago and ate the same amount as always and I went from 234 lbs to 280 lbs very quickly. My Dr. doubled my water pill and within 7 days I lost 14 lbs of water. I was on the verge of congestive heart failure, according to the Doctor. I became weak and had a hard time breathing. Five days ago I went to the E/R and was put into the hosp for 4 days for a cath and observed for 3 more days. I also know that I have taken Avandia before and have checked with Pharmacies trying to locate when I was perscribed Avanida and by whom and can’t find it. I know I was perscribed this drug for Type II. Any ideas on how I could find that out. Avandia should know but I’m sure they would never devolge that information. Any help would be appreciated. Thanks, Konghhop